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RIMD Research Institute for Microbial Diseases 大阪大学微生物病研究所

© Fujimoto Lab, Department of Microbial Regulation, Research Institute for Microbial Diseases (RIMD), the University of Osaka

研究業績Publications

英文論文（原著）

  1. Otani K, Nakatsu G, Fujimoto K, Miyaoka D, Sato N, Nadatani Y, Nishida Y, Maruyama H, Ominami M, Fukunaga S, Hosomi S, Tanaka F, Imoto S, Uematsu S, Watanabe T, Fujiwara Y. Development of gastric mucosa-associated microbiota in autoimmune gastritis with neuroendocrine tumors. J Gastroenterol. in press (2025)
  2. Sato N, Katayama K, Miyaoka D, Uematsu M, Saito A, Fujimoto K, Uematsu S, Imoto S. stana: an R package for metagenotyping analysis and interactive application based on clinical data. NAR Genom Bioinform. 7, lqae191 (2025)
  3. Fujimoto K, Hayashi T, Yamamoto M, Sato N, Shimohigoshi M, Miyaoka D, Yokota C, Watanabe M, Hisaki Y, Kamei Y, Yokoyama Y, Yabuno T, Hirose A, Nakamae M, Nakamae H, Uematsu M, Sato S, Yamaguchi K, Furukawa Y, Akeda Y, Hino M, Imoto S, Uematsu S. An enterococcal phage-derived enzyme suppresses graft-versus-host disease. Nature. 632, 174-181 (2024)
    ＊Nature誌のResearch Briefingsで紹介されました（https://www.nature.com/articles/d41586-024-03188-6）
  4. Watanabe M*, Uematsu M*, Fujimoto K*, Hara T, Yamamoto M, Miyaoka D, Yokota C, Kamei Y, Sugimoto A, Kawasaki N, Yabuno T, Sato N, Sato S, Yamaguchi K, Furukawa Y, Tsuruta D, Okada F, Imoto S, Uematsu S. Targeted Lysis of Staphylococcus hominis Linked to Axillary Osmidrosis Using Bacteriophage-Derived Endolysin. J Invest Dermatol. 144, 2577-2581 (2024) (*co-first author)
  5. Yokota C*, Fujimoto K*, Yamakawa N, Kono M, Miyaoka D, Shimohigoshi M, Uematsu M, Watanabe M, Kamei Y, Sugimoto A, Kawasaki N, Yabuno T, Okamura T, Kuroda E, Hamaguchi S, Sato S, Hotomi M, Akeda Y, Ishii KJ, Yasutomi Y, Sunami K, Uematsu S. Prime-boost-type PspA3 + 2 mucosal vaccine protects cynomolgus macaques from intratracheal challenge with pneumococci. Inflamm Regen. 43, 55 (2023) (*co-first author)
  6. Sato N, Uematsu M, Fujimoto K, Uematsu S, Imoto S. ggkegg: analysis and visualization of KEGG data utilizing the grammar of graphics. Bioinformatics. 39, btad622 (2023)
  7. Zhang YZ, Liu Y, Bai Z, Fujimoto K, Uematsu S, Imoto S. Zero-shot-capable identification of phage-host relationships with whole-genome sequence representation by contrastive learning. Brief Bioinform. 24, bbad239 (2023)
  8. Takaori A, Hashimoto D, Ikeura T, Ito T, Nakamaru K, Masuda M, Nakayama S, Yamaki S, Yamamoto T, Fujimoto K, Matsuo Y, Akagawa S, Ishida M, Yamaguchi K, Imoto S, Hirota K, Uematsu S, Satoi S, Sekimoto M, Naganuma M. Impact of neoadjuvant therapy on gut microbiome in patients with resectable/borderline resectable pancreatic ductal adenocarcinoma. Pancreatology. 23, 367-376 (2023)
  9. Sugiyama Y, Takata K, Kinoshita M, Motooka D, Shiraishi N, Kihara K, Murata H, Beppu S, Koda T, Yamashita K, Namba A, Fujimoto K, Kumanogoh A, Okuno T, Mochizuki H. Food additive succinate exacerbates experimental autoimmune encephalomyelitis accompanied by increased IL-1b production. Biochem Biophys Res Commun. 656, 97-103 (2023)
  10. Bai Z, Zhang YZ, Miyano S, Yamaguchi R, Fujimoto K, Uematsu S, Imoto S. Identification of bacteriophage genome sequences with representation learning. Bioinformatics. 38, 4264-4270 (2022)
  11. Masuhiro K*, Tamiya M*, Fujimoto K*, Koyama S, Naito Y, Osa A, Hirai T, Suzuki H, Okamoto N, Shiroyama T, Nishino K, Adachi Y, Nii T, Kinugasa-Katayama Y, Kajihara A, Morita T, Imoto S, Uematsu S, Irie T, Okuzaki D, Aoshi T, Takeda Y, Kumagai T, Hirashima T, Kumanogoh A. Bronchoalveolar lavage fluid reveals factors contributing to the efficacy of PD-1 blockade in lung cancer. JCI Insight. 7, e157915 (2022) (*co-first author)
  12. Takada N, Takasugi M, Nonaka Y, Kamiya T, Takemura K, Satoh J, Ito S, Fujimoto K, Uematsu S, Yoshida K, Morita T, Nakamura H, Uezumi A, Ohtani N. Galectin-3 promotes the adipogenic differentiation of PDGFRa+ cells and ectopic fat formation in regenerating muscle. Development. 149, dev199443 (2022)
  13. Kosaka S, Nadatani Y, Higashimori A, Otani K, Fujimoto K, Nagata Y, Ominami M, Fukunaga S, Hosomi S, Kamata N, Tanaka F, Nagami Y, Taira K, Imoto S, Uematsu S, Watanabe T, Fujiwara Y. Ovariectomy-Induced Dysbiosis May Have a Minor Effect on Bone in Mice. Microorganisms. 9, 2563 (2021)
  14. Fujimoto K, Kimura Y, Allegretti JR, Yamamoto M, Zhang YZ, Katayama K, Tremmel G, Kawaguchi Y, Shimohigoshi M, Hayashi T, Uematsu M, Yamaguchi K, Furukawa Y, Akiyama Y, Yamaguchi R, Crowe SE, Ernst PB, Miyano S, Kiyono H, Imoto S, Uematsu S. Functional Restoration of Bacteriomes and Viromes by Fecal Microbiota Transplantation. Gastroenterology. 160, 2089-2102.e12. (2021)
    ＊掲載号のカバーイメージに採択されました
  15. Takashima S, Tanaka F, Kawaguchi Y, Usui Y, Fujimoto K, Nadatani Y, Otani K, Hosomi S, Nagami Y, Kamata N, Taira K, Tanigawa T, Watanabe T, Imoto S, Uematsu S, Fujiwara Y. Proton pump inhibitors enhance intestinal permeability via dysbiosis of gut microbiota under stressed conditions in mice. Neurogastroenterol Motil. 32, e13841 (2020)
  16. Fujimoto K, Kimura Y, Shimohigoshi M, Satoh T, Sato S, Tremmel G, Uematsu M, Kawaguchi Y, Usui Y, Nakano Y, Hayashi T, Kashima K, Yuki Y, Yamaguchi K, Furukawa Y, Kakuta M, Akiyama Y, Yamaguchi R, Crowe SE, Ernst PB, Miyano S, Kiyono H, Imoto S, Uematsu S. Metagenome Data on Intestinal Phage-Bacteria Associations Aids the Development of Phage Therapy against Pathobionts. Cell Host Microbe. 28, 380-389.e9. (2020)
    ＊掲載号のPreviewで紹介されました
  17. Pareek S, Kurakawa T, Das B, Motooka D, Nakaya S, Rongsen-Chandola T, Goyal N, Kayama H, Dodd D, Okumura R, Maeda Y, Fujimoto K, Nii T, Ogawa T, Iida T, Bhandari N, Kida T, Nakamura S, Nair GB, Takeda K. Comparison of Japanese and Indian intestinal microbiota shows diet-dependent interaction between bacteria and fungi. NPJ Biofilms Microbiomes. 5, 37 (2019)
  18. Sugimura N, Otani K, Watanabe T, Nakatsu G, Shimada S, Fujimoto K, Nadatani Y, Hosomi S, Tanaka F, Kamata N, Taira K, Nagami Y, Tanigawa T, Uematsu S, Fujiwara Y. High-fat diet-mediated dysbiosis exacerbates NSAID-induced small intestinal damage through the induction of interleukin-17A. Sci Rep. 9, 16796 (2019)
  19. Lee E, Miedzybrodzka EL, Zhang X, Hatano R, Miyamoto J, Kimura I, Fujimoto K, Uematsu S, Rodriguez-Cuenca S, Vidal-Puig A, Gribble FM, Reimann F, Miki T. Diet-Induced Obese Mice and Leptin-Deficient Lep ob/ob Mice Exhibit Increased Circulating GIP Levels Produced by Different Mechanisms. Int J Mol Sci. 20, 4448 (2019)
  20. Fujimoto K, Kawaguchi Y, Shimohigoshi M, Gotoh Y, Nakano Y, Usui Y, Hayashi T, Kimura Y, Uematsu M, Yamamoto T, Akeda Y, Rhee JH, Yuki Y, Ishii KJ, Crowe SE, Ernst PB, Kiyono H, Uematsu S. Antigen-Specific Mucosal Immunity Regulates Development of Intestinal Bacteria-Mediated Diseases. Gastroenterology. 157, 1530-1543.e4 (2019)
  21. Morita T, Shima Y, Fujimoto K, Tsuboi H, Saeki Y, Narazaki M, Ogata A, Kumanogoh A. Anti-receptor activator of nuclear factor kB ligand antibody treatment increases osteoclastogenesis-promoting IL-8 in patients with rheumatoid arthritis. Int Immunol. 31, 277-285 (2019)
  22. Lee EY, Zhang X, Miyamoto J, Kimura I, Taknaka T, Furusawa K, Jomori T, Fujimoto K, Uematsu S, Miki T. Gut carbohydrate inhibits GIP secretion via a microbiota/SCFA/FFAR3 pathway. J Endocrinol. 239, 267-276 (2018)
  23. Osa A*, Uenami T*, Koyama S*, Fujimoto K*, Okuzaki D, Takimoto T, Hirata H, Yano Y, Yokota S, Kinehara Y, Naito Y, Otsuka T, Kanazu M, Kuroyama M, Hamaguchi M, Koba T, Futami Y, Ishijima M, Suga Y, Akazawa Y, Machiyama H, Iwahori K, Takamatsu H, Nagatomo I, Takeda Y, Kida H, Akbay EA, Hammerman PS, Wong KK, Dranoff G, Mori M, Kijima T, Kumanogoh A. Clinical implications of monitoring nivolumab immunokinetics in non-small cell lung cancer patients. JCI Insight. 3, e59125 (2018) (*co-first author)
  24. Usui Y, Kimura Y, Satoh T, Takemura N, Ouchi Y, Ohmiya H, Kobayashi K, Suzuki H, Koyama S, Hagiwara S, Tanaka H, Imoto S, Eberl G, Asami Y, Fujimoto K, Uematsu S. Effects of long-term intake of a yogurt fermented with Lactobacillus delbrueckii subsp. bulgaricus 2038 and Streptococcus thermophilus 1131 on mice. Int Immunol. 30, 319-331 (2018)
  25. Morita T, Fujimoto K, Shima Y, Ogata A, Kumanogoh A. Minimal neonatal transfer of certolizumab pegol in a Japanese patient with rheumatoid arthritis. Ann Rheum Dis. 77, e56 (2018)
  26. Motooka D*, Fujimoto K*, Tanaka R, Yaguchi T, Gotoh K, Maeda Y, Furuta Y, Kurakawa T, Goto N, Yasunaga T, Narazaki M, Kumanogoh A, Horii T, Iida T, Takeda K and Nakamura S. Fungal ITS1 Deep-Sequencing Strategies to Reconstruct the Composition of a 26-Species Community and Evaluation of the Gut Mycobiota of Healthy Japanese Individuals. Front Microbiol. 8, 238 (2017) (*co-first author)
  27. Furuta Y, Tsai SH, Kinoshita M, Fujimoto K, Okumura R, Umemoto E, Kurashima Y, Kiyono H, Kayama H, Takeda K. E-NPP3 controls plasmacytoid dendritic cell numbers in the small intestine. PLoS One. 12, e0172509 (2017)
  28. Fujimoto K, Kinoshita M, Tanaka H, Okuzaki D, Shimada Y, Kayama H, Okumura R, Furuta Y, Narazaki M, Tamura A, Hatakeyama S, Ikawa M, Tsuchiya K, Watanabe M, Kumanogoh A, Tsukita S, Takeda K. Regulation of intestinal homeostasis by the ulcerative colitis-associated gene RNF186. Mucosal Immunol. 10, 446-459 (2017)
    ＊掲載号のカバーイメージに採択されました
  29. Minami S*, Fujimoto K*, Ogata Y, Yamamoto S, Komuta K. Opioids have no negative effect on the survival time of patients with advanced lung cancer in an acute care hospital. Support Care Cancer. 23, 2245-2254 (2015) (*co-first author)
  30. Fujimoto K, Minami S, Yamamoto S, Ogata Y, Koba T, Futami S, Nishijima Y, Yaga M, Masuhiro K, Komuta K. Comparison of timing and decision-makers of do-not-resuscitate orders between thoracic cancer and non-cancer respiratory disease patients dying in a Japanese acute care hospital. Support Care Cancer. 22, 1485-1492 (2014)
  31. Fujimoto K, Karuppuchamy T, Takemura N, Shimohigoshi M, Machida T, Haseda Y, Aoshi T, Ishii KJ, Akira S, Uematsu S. A new subset of CD103+CD8a+ dendritic cells in the small intestine expresses TLR3, TLR7, and TLR9 and induces Th1 response and CTL activity. J Immunol. 186, 6287-6295 (2011)
  32. Uematsu S*, Fujimoto K*, Jang MH, Yang BG, Jung YJ, Nishiyama M, Sato S, Tsujimura T, Yamamoto M, Yokota Y, Kiyono H, Miyasaka M, Ishii KJ, Akira S. Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5. Nature Immunol. 9, 769-76 (2008) (*co-first author)
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